Symposium (Nov. 25-26)

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  • Symposium (Nov. 25-26)

Time Zone: GMT +8 (Taiwan time)

Day 1 (Thursday, November 25)

Moderators: Dr. Yen-Ming Huang, Assistant Professor, National Taiwan University, Taiwan

                     Dr. Fang-Ju Lin, Associate Professor, National Taiwan University, Taiwan

Time

Topic

08:15 - 08:45

Registration

08:45 - 09:00

Welcome and Opening Remarks

  • Yen-Hsuan Ni, MD, PhD

          Dean, College of Medicine, National Taiwan University

  • Jaw-Jou Kang, PhD

         APN Taiwan

         Dean, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University

  • Kyungsoo Park, PhD, MD

         Chair, Asian Pharmacometrics Network

         Yonsei University, Korea

09:00 – 10:00

Plenary Lecture 1: Concentration Controlled Dosing – TDM is Dead! Long Live TCI!

Speaker:

Nick Holford, M.B., Ch.B.

Professor, University of Auckland, New Zealand

Session Chairs:

  • Yoke-Lin Lo, PhD

Associate Professor, International Medical University, Malaysia

  • Chun-Jung Lin, PhD

Professor, National Taiwan University, Taiwan

10:00 - 10:15

Group Photo

10:15 - 10:30

Break 1

10:30 - 11:00

Pharmacometrics in Taiwan: Academic, Regulatory, Clinical, and Industry Implications

Speaker:

Chen-Hsi Chou, PhD

Associate Professor, National Cheng Kung University, Taiwan

Session Chairs:

  • Uthpali Mannapperuma, PhD

Senior Lecturer University of Colombo, Sri Lanka

  • Chun-Jung Lin, PhD

Professor, National Taiwan University, Taiwan

11:00 - 11:30

Pharmacometrics in Japan

Speaker:

Takahiko Tanigawa, PhD

Bayer Yakuhin, Ltd., Japan

PPKPD for Drug Development General Incorporated Association, Japan

Session Chairs:

  • Atsunori Kaibara, PhD

Eli Lilly, Japan

  • Li-Heng Pao, PhD
Professor, Chang Gung University of Science of Technology, Taiwan

11:30 - 12:00

The Strategy of Sparse Data Sampling in the Pharmacokinetic Study of Levofloxacin

Speaker:

Akhmad Kharis Nugroho, PhD

Professor, Universitas Gadjah Mada, Indonesia

Session Chairs:

  • Atsunori Kaibara, PhD

Eli Lilly, Japan

  • Li-Heng Pao. PhD

Professfor, Chang Gung University of Science of Technology, Taiwan​

12:00 - 13:00

Lunch

13:00 - 13:30

Role of Model-Informed Drug Development in Confirming Additional Clinical Benefits of Dulaglutide

Speaker:

Lai San Tham, PhD

Eli Lilly, Singapore

Session Chairs:

  • Surulivel Rajan Mallayasamy, PhD

Associate Professor, Manipal Academy of Higher Education, India

  • Yu-Tse Wu, PhD

Associate Professor, School of Pharmacy, Kaohsiung Medical University, Taiwan

13:30 - 14:00

A Translational Platform Physiologically-based Pharmacokinetic Model for Antibody Disposition in the Brain

Speaker:

Hsueh-Yuan Chang, PhD

Boehringer Ingelheim, USA

Session Chairs:

  • Surulivel Rajan Mallayasamy, PhD

Associate Professor, Manipal Academy of Higher Education, India

  • Yu-Tse Wu, PhD

Associate Professor, School of Pharmacy, Kaohsiung Medical University, Taiwan

14:00 – 14:30

Population Longitudinal Analysis of Magnetic Resonance Imaging (MRI) and Time to Climb Four Stairs (4SC) in DMD Patients receiving Domagrozumab

Speaker:

Jiexin Deng, PhD

Pfizer, China

Session Chairs:

  • Surulivel Rajan Mallayasamy, PhD

Associate Professor, Manipal Academy of Higher Education, India

  • Yu-Tse Wu, PhD

Associate Professor, School of Pharmacy, Kaohsiung Medical University, Taiwan

14:30 - 15:00

Break 2

15:00 - 15:30

Dose Individualization of Vancomycin: from TDM to MIPD

Speaker:

Dinh Hoa Vu, PhD

National DI and ADR Center, Vietnam

Session Chairs:

  • Manh Hung Tran, PhD

Professor, University of Medicine and Pharmacy, Viet Nam

  • Teh-Min Hu, PhD
Professor, National Yang-Ming Chiao Tung University, Taiwan

15:30 - 16:30

(15 min per presentation)

Oral Presentation:

Session Chairs:

  • Muhammad Usman, PhD

Assistant Professor, University of Veterinary and Animal Sciences, Pakistan

  • Teh-Min Hu, PhD

Professor, National Yang-Ming Chiao Tung University, Taiwan

I. Population Pharmacokinetics of Ciprofloxacin in Pakistani Patients Suffering from Enteric Fever

Presenter:

Rabia Saleem

Lahore Medical and Dental College, Pakistan

II. Using Physiologically based Pharmacokinetic (PBPK) Modeling for the Development of Long Acting Injectable Formulations

Presenter:

Chih-Sheng Hsu

Taipei Medical University, Taiwan

III. Generalizable Model Development for Tacrolimus in Adult Renal Transplant Recipients: Pharmacometric Simulations Approach

Presenter:

Arun Prasath R, PharmD (PhD candidate)

Manipal Academy of Higher Education, India

IV. Model-based Risk Prediction of Rivaroxaban with Amiodarone for Moderate Renal Impaired Elderly Population

Presenter:

Ziteng Wang, PhD

National University of Singapore, Singapore

16:30 - 16:45

Closure of Day 1

Yunn-Fang Ho, PhD

Associate professor, National Taiwan University, Taiwan



Day 2 (Friday, November 26)

Moderators: Dr. Fang-Ju Lin, Associate Professor, National Taiwan University, Taiwan

                    Mr. Ethan Lu, B.Pharm, National Taiwan University, Taiwan

Time

Topic

08:15 - 09:00

Registration

09:00 – 10:00

Plenary Lecture 2: Regulatory Science Perspective on Clinical Pharmacology Strategy for Drug Development

Speaker:

Shiew-Mei Huang, PhD

Food & Drug Administration, USA

Session Chairs:

  • Jaw-Jou Kang, PhD

Professor, National Yang-Ming Chiao Tung University, Taiwan

  • Rujia Xie, PhD

Pfizer, Singapore

10:00 - 10:15

Group Photo

10:15 - 10:30

Break 1

10:30 - 11:00

Establishing Quantitative Science Platforms to Support Global Health Product Development

Speaker:

Ping Zhao, PhD

Bill & Melinda Gates Foundation, USA

Session Chairs:

  • Jaw-Jou Kang, PhD

Professor, National Yang-Ming Chiao Tung University, Taiwan

  • Rujia Xie, PhD

Pfizer, Singapore

11:00 - 11:30

Application of Pharmacometric Approaches to Accelerate the Development of COVID-19 Therapeutics

Speaker:

Jenny Yueh Ling Chien, PhD

Eli Lilly, USA

Session Chairs:

  • Lai San Tham, PhD

Eli Lilly, Singapore

  • Chin-Chuan Hung, PhD

Professor, China Medical University, Taiwan

11:30 - 12:00

Dose Optimization of Vancomycin among Surgical Patients in Pakistan: A Population Pharmacokinetic Approach

Speaker:

Muhammad Usman, PhD

Assistant Professor, University of Veterinary and Animal Sciences, Pakistan

Session Chairs:

  • Lai San Tham, PhD

Eli Lilly, Singapore

  • Chin-Chuan Hung, PhD

Professor, China Medical University, Taiwan

12:00 - 13:00

Lunch

13:00 - 14:00

Plenary Lecture 3: The Use of Real-World Data in Drug Development

Speaker:

Kyungsoo Park, PhD, MD

Professor, Yonsei University, Korea

Session Chairs:

  • Korbtham Sathirakul, PhD

Associate professor, Mahidol University, Thailand

  • Surulivel Rajan Mallayasamy, PhD

Associate Professor, Manipal Academy of Higher Education, India

14:00 – 14:30

Therapeutic Pharmacometric Models and Their Application in Design of Dosage Regimen

Speaker:

Surulivel Rajan Mallayasamy, PhD

Associate Professor, Manipal Academy of Higher Education, India

Session Chairs:

  • Korbtham Sathirakul, PhD

Associate professor, Mahidol University, Thailand

  • Chen-Hsi Chou, PhD

Associate Professor, National Cheng Kung University, Taiwan

14:30 - 15:00

Break 2

15:00 - 15:30

Towards Precision Dosing in Oncology: Modeling of 5-Fluorouracil as an Example

Speaker:

Yunn-Fang Ho, PhD

Associate professor, National Taiwan University, Taiwan

Session Chairs:

  • Korbtham Sathirakul, PhD

Associate professor, Mahidol University, Thailand

  • Chen-Hsi Chou, PhD

Associate Professor, National Cheng Kung University, Taiwan

15:30 - 16:15

(15 min per presentation)

Oral Presentation:

Session Chairs:

  • Akhmad Kharis Nugroho, PhD

Professor, Universitas Gadjah Mada, Indonesia

  • Chien-Ming Hsieh, PhD

Associate Professor, Taipei Medical University, Taiwan

I. An Optimal Dosage Regimen Design Scheme to Minimize Paclitaxel and Cisplatin Induced Myelosuppression in Non-small Cell Lung Cancer

Presenter:

Kyemyung Park, MD, PhD (Postdoctoral fellow)

Yonsei University, Korea

II. Classification Tree Analysis Based on Machine Learning for Predicting Linezolid-Induced Thrombocytopenia

Presenter:

Saki Takahashi

University of Toyama, Japan

III. Predictive Performance of Population Pharmacokinetic Models of Amikacin in Neonates

Presenter:

Saikumar Matcha, PharmD (PhD Candidate)

Manipal Academy of Higher Education, India

16:15-16:45

Population Pharmacokinetics and Dosing Simulations of Oxycodone in Adult Surgical Patients with Obesity

Speaker:

Sook Hui Chaw, MD

Associate Professor, University of Malaya, Malaysia

Session Chairs:

  • Yoke-Lin Lo, PhD

Associate Professor, International Medical University, Malaysia

  • Bimal Kunwar, PhD

Nobel College of Health Science, Nepal

16:45 - 17:00

Closing Remark

Kyungsoo Park, PhD, MD

Chair, Asian Pharmacometrics Network

  •  e-Poster: Poster & Presenter's 2-3 min oral introduction

The e-Posters will be presented in the 2021 APN e-poster's gallery and will be available for viewing for participants at all times during the symposium.